Identification of the major adducts formed by reaction of benzo(a)pyrene diol epoxide with DNA in vitro.

Covalent binding of the benzo[a]pyrene metabolite (+/-)7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene to calf thymus DNA was investigated. Enzymatic hydrolysis of the carcinogen-modified DNA and subsequent separation via reversed-phase high-pressure liquid chromatograp...

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Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Straub, K M, Meehan, T, Burlingame, A L, Calvin, M
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1977
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC431688/
https://ncbi.nlm.nih.gov/pubmed/271953
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