Human RNA polymerase II is partially blocked by DNA adducts derived from tumorigenic benzo[c]phenanthrene diol epoxides: relating biological consequences to conformational preferences

Environmental polycyclic aromatic hydrocarbons (PAHs) are metabolically activated to diol epoxides that can react with DNA, resulting in covalent modifications to the bases. The (+)- and (–)-3,4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydro-benzo[c]phenanthrene (anti-BPhDE) isomers are diol epoxide metabol...

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Hlavní autoři: Schinecker, Thomas M., Perlow, Rebecca A., Broyde, Suse, Geacintov, Nicholas E., Scicchitano, David A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2003
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC219463/
https://ncbi.nlm.nih.gov/pubmed/14530448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg771
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