Human RNA polymerase II is partially blocked by DNA adducts derived from tumorigenic benzo[c]phenanthrene diol epoxides: relating biological consequences to conformational preferences

Environmental polycyclic aromatic hydrocarbons (PAHs) are metabolically activated to diol epoxides that can react with DNA, resulting in covalent modifications to the bases. The (+)- and (–)-3,4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydro-benzo[c]phenanthrene (anti-BPhDE) isomers are diol epoxide metabol...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Schinecker, Thomas M., Perlow, Rebecca A., Broyde, Suse, Geacintov, Nicholas E., Scicchitano, David A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 2003
Assuntos:	Articles
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC219463/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14530448/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg771
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