Identification of the major adducts formed by reaction of benzo(a)pyrene diol epoxide with DNA in vitro.
Covalent binding of the benzo[a]pyrene metabolite (+/-)7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene to calf thymus DNA was investigated. Enzymatic hydrolysis of the carcinogen-modified DNA and subsequent separation via reversed-phase high-pressure liquid chromatograp...
محفوظ في:
| الحاوية / القاعدة: | Proc Natl Acad Sci U S A |
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| المؤلفون الرئيسيون: | , , , |
| التنسيق: | Artigo |
| اللغة: | Inglês |
| منشور في: |
National Academy of Sciences
1977
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC431688/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/271953/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.74.12.5285 |
| الوسوم: |
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