DNA Polymerase Eta Participates in the Mutagenic Bypass of Adducts Induced by Benzo[a]pyrene Diol Epoxide in Mammalian Cells

Y-family DNA-polymerases have larger active sites that can accommodate bulky DNA adducts allowing them to bypass these lesions during replication. One member, polymerase eta (pol eta), is specialized for the bypass of UV-induced thymidine-thymidine dimers, correctly inserting two adenines. Loss of p...

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Auteurs principaux: Klarer, Alden C., Stallons, L. Jay, Burke, Tom J., Skaggs, Robert L., McGregor, W. Glenn
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2012
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3380003/
https://ncbi.nlm.nih.gov/pubmed/22745795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039596
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