Evidence for Pore Formation in Host Cell Membranes by ESX-1-Secreted ESAT-6 and Its Role in Mycobacterium marinum Escape from the Vacuole

The ESX-1 secretion system plays a critical role in the virulence of M. tuberculosis and M. marinum, but the precise molecular and cellular mechanisms are not clearly defined. Virulent M. marinum is able to escape from the Mycobacterium-containing vacuole (MCV) into the host cell cytosol, polymerize...

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Bibliographische Detailangaben
Hauptverfasser: Smith, Jennifer, Manoranjan, Joanna, Pan, Miao, Bohsali, Amro, Xu, Junjie, Liu, Jun, McDonald, Kent L., Szyk, Agnieszka, LaRonde-LeBlanc, Nicole, Gao, Lian-Yong
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2008
Schlagworte:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583575/
https://ncbi.nlm.nih.gov/pubmed/18852239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00614-08
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