Evidence for Pore Formation in Host Cell Membranes by ESX-1-Secreted ESAT-6 and Its Role in Mycobacterium marinum Escape from the Vacuole

The ESX-1 secretion system plays a critical role in the virulence of M. tuberculosis and M. marinum, but the precise molecular and cellular mechanisms are not clearly defined. Virulent M. marinum is able to escape from the Mycobacterium-containing vacuole (MCV) into the host cell cytosol, polymerize...

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Main Authors: Smith, Jennifer, Manoranjan, Joanna, Pan, Miao, Bohsali, Amro, Xu, Junjie, Liu, Jun, McDonald, Kent L., Szyk, Agnieszka, LaRonde-LeBlanc, Nicole, Gao, Lian-Yong
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2008
Teme:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583575/
https://ncbi.nlm.nih.gov/pubmed/18852239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00614-08
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