Evidence for Pore Formation in Host Cell Membranes by ESX-1-Secreted ESAT-6 and Its Role in Mycobacterium marinum Escape from the Vacuole

The ESX-1 secretion system plays a critical role in the virulence of M. tuberculosis and M. marinum, but the precise molecular and cellular mechanisms are not clearly defined. Virulent M. marinum is able to escape from the Mycobacterium-containing vacuole (MCV) into the host cell cytosol, polymerize...

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Detalhes bibliográficos
Main Authors: Smith, Jennifer, Manoranjan, Joanna, Pan, Miao, Bohsali, Amro, Xu, Junjie, Liu, Jun, McDonald, Kent L., Szyk, Agnieszka, LaRonde-LeBlanc, Nicole, Gao, Lian-Yong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583575/
https://ncbi.nlm.nih.gov/pubmed/18852239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00614-08
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