A Novel ESX-1 Locus Reveals that Surface-Associated ESX-1 Substrates Mediate Virulence in Mycobacterium marinum

EsxA (ESAT-6) and EsxB (CFP-10) are virulence factors exported by the ESX-1 system in mycobacterial pathogens. In Mycobacterium marinum, an established model for ESX-1 secretion in Mycobacterium tuberculosis, genes required for ESX-1 export reside at the extended region of difference 1 (RD1) locus....

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Hlavní autoři: Kennedy, George M., Hooley, Gwendolyn C., Champion, Matthew M., Mba Medie, Felix, Champion, Patricia A. DiGiuseppe
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4011007/
https://ncbi.nlm.nih.gov/pubmed/24610712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.01502-14
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