ELEVATED GLUTATHIONE LEVELS CONFER CELLULAR SENSITIZATION TO CISPLATIN TOXICITY BY UPREGULATION OF COPPER TRANSPORTER HCTR1

Previous studies have demonstrated that treating cultured cells with cisplatin (CDDP) upregulated the expression of glutathione (GSH) and its de novo rate-limiting enzyme, glutamate-cysteine ligase (GCL), which consists of a catalytic (GCLC) and a modifier (GCLM) subunits. It has also been shown tha...

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Détails bibliographiques
Auteurs principaux: Chen, Helen H. W., Song, Im-Sook, Hossain, Anwar, Choi, Min-Koo, Yamane, Yoshiaki, Liang, Zheng D., Lu, Jia, Wu, Lily Y-H, Siddik, Zahid H., Klomp, Leo W. J., Savaraj, Niramol, Tien, Kuo Macus
Format: Artigo
Langue:Inglês
Publié: 2008
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583459/
https://ncbi.nlm.nih.gov/pubmed/18523133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.047969
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