ELEVATED GLUTATHIONE LEVELS CONFER CELLULAR SENSITIZATION TO CISPLATIN TOXICITY BY UPREGULATION OF COPPER TRANSPORTER HCTR1

Previous studies have demonstrated that treating cultured cells with cisplatin (CDDP) upregulated the expression of glutathione (GSH) and its de novo rate-limiting enzyme, glutamate-cysteine ligase (GCL), which consists of a catalytic (GCLC) and a modifier (GCLM) subunits. It has also been shown tha...

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Hlavní autoři: Chen, Helen H. W., Song, Im-Sook, Hossain, Anwar, Choi, Min-Koo, Yamane, Yoshiaki, Liang, Zheng D., Lu, Jia, Wu, Lily Y-H, Siddik, Zahid H., Klomp, Leo W. J., Savaraj, Niramol, Tien, Kuo Macus
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583459/
https://ncbi.nlm.nih.gov/pubmed/18523133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.047969
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