ELEVATED GLUTATHIONE LEVELS CONFER CELLULAR SENSITIZATION TO CISPLATIN TOXICITY BY UPREGULATION OF COPPER TRANSPORTER HCTR1

Previous studies have demonstrated that treating cultured cells with cisplatin (CDDP) upregulated the expression of glutathione (GSH) and its de novo rate-limiting enzyme, glutamate-cysteine ligase (GCL), which consists of a catalytic (GCLC) and a modifier (GCLM) subunits. It has also been shown tha...

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Detalhes bibliográficos
Main Authors: Chen, Helen H. W., Song, Im-Sook, Hossain, Anwar, Choi, Min-Koo, Yamane, Yoshiaki, Liang, Zheng D., Lu, Jia, Wu, Lily Y-H, Siddik, Zahid H., Klomp, Leo W. J., Savaraj, Niramol, Tien, Kuo Macus
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583459/
https://ncbi.nlm.nih.gov/pubmed/18523133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.047969
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