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Efficient in vivo gene expression by trans-splicing adeno-associated viral vectors
Although adeno-associated virus (AAV)-mediated gene therapy has been hindered by the small viral packaging capacity of the vector, trans-splicing AAV vectors are able to package twice the size of the vector genome. Unfortunately, the efficiency of current trans-splicing vectors is very low. Here we...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2005
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2581721/ https://ncbi.nlm.nih.gov/pubmed/16244658 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt1153 |
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