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Synthetic Intron Improves Transduction Efficiency of Trans-Splicing Adeno-Associated Viral Vectors
Trans-splicing adeno-associated viral (AAV) vectors hold great promise in many gene therapy applications. We have shown that rational selection of the gene-splitting site in a therapeutic target gene can lead to extremely efficient trans-splicing vectors [Lai, Y., Yue, Y., Liu, M., Ghosh, A., Engelh...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2431463/ https://ncbi.nlm.nih.gov/pubmed/17007565 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2006.17.ft-246 |
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