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Efficient in vivo gene expression by trans-splicing adeno-associated viral vectors

Although adeno-associated virus (AAV)-mediated gene therapy has been hindered by the small viral packaging capacity of the vector, trans-splicing AAV vectors are able to package twice the size of the vector genome. Unfortunately, the efficiency of current trans-splicing vectors is very low. Here we...

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Detalhes bibliográficos
Main Authors: Lai, Yi, Yue, Yongping, Liu, Mingju, Ghosh, Arkasubhra, Engelhardt, John F, Chamberlain, Jeffrey S, Duan, Dongsheng
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2581721/
https://ncbi.nlm.nih.gov/pubmed/16244658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt1153
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