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Trans-Splicing Adeno-Associated Viral Vector-Mediated Gene Therapy Is Limited by the Accumulation of Spliced mRNA but Not by Dual Vector Coinfection Efficiency

Therapeutic application of recombinant adeno-associated virus (AAV) has been limited by its small carrying capacity. To overcome this limitation trans-splicing vectors were developed recently. However, the transduction efficiency of trans-splicing vectors is considerably lower than that of a single...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: XU, ZHUPING, YUE, YONGPING, LAI, YI, YE, CHAOYANG, QIU, JIANMING, PINTEL, DAVID J., DUAN, DONGSHENG
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2004
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2431462/
https://ncbi.nlm.nih.gov/pubmed/15353044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2004.15.896
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