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Stereochemistry Modulates Stability of Reduced Inter-Strand Cross-Links Arising From R- and S-α-CH(3)-γ-OH-1,N(2)-propano-2′-Deoxyguanosine in the 5′-CpG-3′ DNA Sequence
The solution structures of 5′-Cp-N(2)-dG-3′-R-(α)-CH(3)-propyl-5′-Cp-N(2)-dG-3′ and 5′-Cp-N(2)-dG-3′- S-(α)-CH(3)-propyl-5′-Cp-N(2)-dG-3′ inter-strand DNA cross-links in the 5′-CpG-3′ sequence were determined by NMR spectroscopy. These were utilized as chemically stable surrogates for the correspond...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2581467/ https://ncbi.nlm.nih.gov/pubmed/17305317 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi061381h |
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