Segregation and activation of myosin IIB creates a rear in migrating cells

We have found that MLC-dependent activation of myosin IIB in migrating cells is required to form an extended rear, which coincides with increased directional migration. Activated myosin IIB localizes prominently at the cell rear and produces large, stable actin filament bundles and adhesions, which...

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Hauptverfasser: Vicente-Manzanares, Miguel, Koach, Margaret A., Whitmore, Leanna, Lamers, Marcelo L., Horwitz, Alan F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2008
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575793/
https://ncbi.nlm.nih.gov/pubmed/18955554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200806030
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