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Myosin Light Chain Mono- and Di-Phosphorylation Differentially Regulate Adhesion and Polarity in Migrating Cells

Myosin II is a critical regulator of cell migration that generates polarity, controls protrusion, and promotes adhesion maturation and retraction of the rear. Myosin II has an ATPase motor domain that is regulated by phosphorylation of the regulatory light chain (RLC) on Thr18 and Ser19. Here, we ad...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Vicente-Manzanares, Miguel, Horwitz, Alan Rick
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2991406/
https://ncbi.nlm.nih.gov/pubmed/20971064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2010.10.071
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