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Myosin IIA/IIB restrict adhesive and protrusive signaling to generate front–back polarity in migrating cells

Migratory front–back polarity emerges from the cooperative effect of myosin IIA (MIIA) and IIB (MIIB) on adhesive signaling. We demonstrate here that, during polarization, MIIA and MIIB coordinately promote localized actomyosin bundling, which generates large, stable adhesions that do not signal to...

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Bibliografiske detaljer
Main Authors: Vicente-Manzanares, Miguel, Newell-Litwa, Karen, Bachir, Alexia I., Whitmore, Leanna A., Horwitz, Alan Rick
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3080254/
https://ncbi.nlm.nih.gov/pubmed/21482721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201012159
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