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Myosin IIA/IIB restrict adhesive and protrusive signaling to generate front–back polarity in migrating cells

Migratory front–back polarity emerges from the cooperative effect of myosin IIA (MIIA) and IIB (MIIB) on adhesive signaling. We demonstrate here that, during polarization, MIIA and MIIB coordinately promote localized actomyosin bundling, which generates large, stable adhesions that do not signal to...

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Detalhes bibliográficos
Main Authors: Vicente-Manzanares, Miguel, Newell-Litwa, Karen, Bachir, Alexia I., Whitmore, Leanna A., Horwitz, Alan Rick
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3080254/
https://ncbi.nlm.nih.gov/pubmed/21482721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201012159
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