Myosin IIA/IIB restrict adhesive and protrusive signaling to generate front–back polarity in migrating cells

Migratory front–back polarity emerges from the cooperative effect of myosin IIA (MIIA) and IIB (MIIB) on adhesive signaling. We demonstrate here that, during polarization, MIIA and MIIB coordinately promote localized actomyosin bundling, which generates large, stable adhesions that do not signal to...

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Detaylı Bibliyografya
Asıl Yazarlar: Vicente-Manzanares, Miguel, Newell-Litwa, Karen, Bachir, Alexia I., Whitmore, Leanna A., Horwitz, Alan Rick
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Rockefeller University Press 2011
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3080254/
https://ncbi.nlm.nih.gov/pubmed/21482721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201012159
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