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Regulation of protrusion, adhesion dynamics, and polarity by myosins IIA and IIB in migrating cells

We have used isoform-specific RNA interference knockdowns to investigate the roles of myosin IIA (MIIA) and MIIB in the component processes that drive cell migration. Both isoforms reside outside of protrusions and act at a distance to regulate cell protrusion, signaling, and maturation of nascent a...

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Main Authors: Vicente-Manzanares, Miguel, Zareno, Jessica, Whitmore, Leanna, Choi, Colin K., Horwitz, Alan F.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064016/
https://ncbi.nlm.nih.gov/pubmed/17312025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200612043
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