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Actin and α-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner

Using two-colour imaging and high resolution TIRF microscopy, we investigated the assembly and maturation of nascent adhesions in migrating cells. We show that nascent adhesions assemble and are stable within the lamellipodium. The assembly is independent of myosin II but its rate is proportional to...

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Main Authors: Choi, Colin K., Vicente-Manzanares, Miguel, Zareno, Jessica, Whitmore, Leanna A., Mogilner, Alex, Horwitz, Alan Rick
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2827253/
https://ncbi.nlm.nih.gov/pubmed/19160484
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