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Segregation and activation of myosin IIB creates a rear in migrating cells

We have found that MLC-dependent activation of myosin IIB in migrating cells is required to form an extended rear, which coincides with increased directional migration. Activated myosin IIB localizes prominently at the cell rear and produces large, stable actin filament bundles and adhesions, which...

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Main Authors: Vicente-Manzanares, Miguel, Koach, Margaret A., Whitmore, Leanna, Lamers, Marcelo L., Horwitz, Alan F.
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575793/
https://ncbi.nlm.nih.gov/pubmed/18955554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200806030
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