Activated Akt1 accelerates MMTV-c-ErbB2 mammary tumourigenesis in mice without activation of ErbB3

INTRODUCTION: ErbB2, a member of the epidermal growth factor receptor (EGFR) family, is overexpressed in 20% to 30% of human breast cancer cases and forms oncogenic signalling complexes when dimerised to ErbB3 or other EGFR family members. METHODS: We crossed mouse mammary tumour virus (MMTV)-myr-Ak...

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Hlavní autoři: Young, Christian D, Nolte, Erica C, Lewis, Andrew, Serkova, Natalie J, Anderson, Steven M
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2008
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575543/
https://ncbi.nlm.nih.gov/pubmed/18700973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2132
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