Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage

Mutation of the RB-1 and p53 tumor suppressors is associated with the development of human osteosarcoma. With the goal of generating a mouse model of this disease, we used conditional and transgenic mouse strains to inactivate Rb and/or p53 specifically in osteoblast precursors. The resulting Rb;p53...

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Main Authors: Berman, Seth D., Calo, Eliezer, Landman, Allison S., Danielian, Paul S., Miller, Emily S., West, Julie C., Fonhoue, Borel Djouedjong, Caron, Alicia, Bronson, Roderick, Bouxsein, Mary L., Mukherjee, Siddhartha, Lees, Jacqueline A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575280/
https://ncbi.nlm.nih.gov/pubmed/18697945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805462105
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