Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage

Mutation of the RB-1 and p53 tumor suppressors is associated with the development of human osteosarcoma. With the goal of generating a mouse model of this disease, we used conditional and transgenic mouse strains to inactivate Rb and/or p53 specifically in osteoblast precursors. The resulting Rb;p53...

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Autors principals: Berman, Seth D., Calo, Eliezer, Landman, Allison S., Danielian, Paul S., Miller, Emily S., West, Julie C., Fonhoue, Borel Djouedjong, Caron, Alicia, Bronson, Roderick, Bouxsein, Mary L., Mukherjee, Siddhartha, Lees, Jacqueline A.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2008
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575280/
https://ncbi.nlm.nih.gov/pubmed/18697945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805462105
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