Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage

Mutation of the RB-1 and p53 tumor suppressors is associated with the development of human osteosarcoma. With the goal of generating a mouse model of this disease, we used conditional and transgenic mouse strains to inactivate Rb and/or p53 specifically in osteoblast precursors. The resulting Rb;p53...

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Detalhes bibliográficos
Main Authors: Berman, Seth D., Calo, Eliezer, Landman, Allison S., Danielian, Paul S., Miller, Emily S., West, Julie C., Fonhoue, Borel Djouedjong, Caron, Alicia, Bronson, Roderick, Bouxsein, Mary L., Mukherjee, Siddhartha, Lees, Jacqueline A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575280/
https://ncbi.nlm.nih.gov/pubmed/18697945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805462105
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