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Selective Requirements for E2f3 in the Development and Tumorigenicity of Rb-Deficient Chimeric Tissues

The tumor suppressor function of the retinoblastoma protein pRB is largely dependent upon its capacity to inhibit the E2F transcription factors and thereby cell proliferation. Attempts to study the interplay between pRB and the E2Fs have been hampered by the prenatal death of Rb; E2f nullizygous mic...

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Autori principali: Parisi, Tiziana, Yuan, Tina L., Faust, Ann Marie, Caron, Alicia M., Bronson, Roderick, Lees, Jacqueline A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1820513/
https://ncbi.nlm.nih.gov/pubmed/17210634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01854-06
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