E2F3 Loss Has Opposing Effects on Different pRB-Deficient Tumors, Resulting in Suppression of Pituitary Tumors but Metastasis of Medullary Thyroid Carcinomas

The E2F transcription factors are key downstream targets of the retinoblastoma protein (pRB) tumor suppressor. We have previously shown that E2F3 plays a critical role in mediating the mitogen-induced activation of E2F-responsive genes and contributes to both the inappropriate proliferation and the...

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Autores principales: Ziebold, Ulrike, Lee, Eunice Y., Bronson, Roderick T., Lees, Jacqueline A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2003
Materias:
Cell Growth and Development
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC193688/
https://ncbi.nlm.nih.gov/pubmed/12944480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.18.6542-6552.2003
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