Histone deacetylase-dependent transcriptional repression by pRB in yeast occurs independently of interaction through the LXCXE binding cleft

We have developed a yeast model system to address transcriptional repression by the retinoblastoma protein (pRB). When fused to the DNA-binding domain of Gal4p (DB-pRB), pRB can repress transcription of reporter genes containing Gal4p binding sites; the histone deacetylase activity encoded by yeast...

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Bibliographic Details
Main Authors: Kennedy, Brian K., Liu, Oliver W., Dick, Fred A., Dyson, Nick, Harlow, Ed, Vidal, Marc
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2001
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC37502/
https://ncbi.nlm.nih.gov/pubmed/11447271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.151240898
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