Histone deacetylase-dependent transcriptional repression by pRB in yeast occurs independently of interaction through the LXCXE binding cleft

We have developed a yeast model system to address transcriptional repression by the retinoblastoma protein (pRB). When fused to the DNA-binding domain of Gal4p (DB-pRB), pRB can repress transcription of reporter genes containing Gal4p binding sites; the histone deacetylase activity encoded by yeast...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Kennedy, Brian K., Liu, Oliver W., Dick, Fred A., Dyson, Nick, Harlow, Ed, Vidal, Marc
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC37502/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11447271/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.151240898
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