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E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos
The E2F transcription factors are thought to be key downstream targets of the retinoblastoma protein (pRB) tumor suppressor. It is widely believed that E2F1, E2F2, and E2F3 can all activate cellular proliferation but that E2F1 is the specific inducer of apoptosis. Here we show that the E2f3 mutation...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cold Spring Harbor Laboratory Press
2001
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC312633/ https://ncbi.nlm.nih.gov/pubmed/11230146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.858801 |
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