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Evolution Rescues Folding of Human Immunodeficiency Virus-1 Envelope Glycoprotein GP120 Lacking a Conserved Disulfide Bond

The majority of eukaryotic secretory and membrane proteins contain disulfide bonds, which are strongly conserved within protein families because of their crucial role in folding or function. The exact role of these disulfide bonds during folding is unclear. Using virus-driven evolution we generated...

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Main Authors: Sanders, Rogier W., Hsu, Shang-Te D., van Anken, Eelco, Liscaljet, I. Marije, Dankers, Martijn, Bontjer, Ilja, Land, Aafke, Braakman, Ineke, Bonvin, Alexandre M.J.J., Berkhout, Ben
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Cell Biology 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575144/
https://ncbi.nlm.nih.gov/pubmed/18753405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E08-07-0670
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