Structure and topology around the cleavage site regulate post-translational cleavage of the HIV-1 gp160 signal peptide

Like all other secretory proteins, the HIV-1 envelope glycoprotein gp160 is targeted to the endoplasmic reticulum (ER) by its signal peptide during synthesis. Proper gp160 folding in the ER requires core glycosylation, disulfide-bond formation and proline isomerization. Signal-peptide cleavage occur...

Full description

Saved in:
Bibliographic Details
Published in:eLife
Main Authors: Snapp, Erik Lee, McCaul, Nicholas, Quandte, Matthias, Cabartova, Zuzana, Bontjer, Ilja, Källgren, Carolina, Nilsson, IngMarie, Land, Aafke, von Heijne, Gunnar, Sanders, Rogier W, Braakman, Ineke
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2017
Subjects:
Biochemistry and Chemical Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5577925/
https://ncbi.nlm.nih.gov/pubmed/28753126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.26067
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items