Evolution of the HIV-1 envelope glycoproteins with a disulfide bond between gp120 and gp41

BACKGROUND: We previously described the construction of an HIV-1 envelope glycoprotein complex (Env) that is stabilized by an engineered intermolecular disulfide bond (SOS) between gp120 and gp41. The modified Env protein antigenically mimics the functional wild-type Env complex. Here, we explore th...

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Main Authors: Sanders, Rogier W, Dankers, Martijn M, Busser, Els, Caffrey, Michael, Moore, John P, Berkhout, Ben
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2004
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC416572/
https://ncbi.nlm.nih.gov/pubmed/15169554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-1-3
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