A Recombinant Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Complex Stabilized by an Intermolecular Disulfide Bond between the gp120 and gp41 Subunits Is an Antigenic Mimic of the Trimeric Virion-Associated Structure

The few antibodies that can potently neutralize human immunodeficiency virus type 1 (HIV-1) recognize the limited number of envelope glycoprotein epitopes exposed on infectious virions. These native envelope glycoprotein complexes comprise three gp120 subunits noncovalently and weakly associated wit...

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Detalhes bibliográficos
Main Authors: Binley, James M., Sanders, Rogier W., Clas, Brian, Schuelke, Norbert, Master, Aditi, Guo, Yong, Kajumo, Francis, Anselma, Deborah J., Maddon, Paul J., Olson, William C., Moore, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC111582/
https://ncbi.nlm.nih.gov/pubmed/10623724
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