Generation of New Derivatives of the Antitumor Antibiotic Mithramycin by Altering the Glycosylation Pattern through Combinatorial Biosynthesis

Mithramycin is an antitumor drug produced by Streptomyces argillaceus. It consists of a tricyclic aglycone and five deoxyhexoses that form a disaccharide and a trisaccharide chain, which are important for target interaction and therefore for the antitumor activity. Using a combinatorial biosynthesis...

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Autors principals: Pérez, María, Baig, Irfan, Braña, Alfredo F., Salas, José A., Rohr, Jürgen, Méndez, Carmen
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574993/
https://ncbi.nlm.nih.gov/pubmed/18756551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.200800299
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