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Mithramycin SK, A Novel Antitumor Drug with Improved Therapeutic Index, Mithramycin SA, and Demycarosyl-mithramycin SK: Three New Products Generated in the Mithramycin Producer Streptomyces argillaceus through Combinatorial Biosynthesis

To gain initial structure–activity relationships regarding the highly functionalized pentyl side chain attached at C-3 of mithramycin (MTM), we focused on a post-polyketide synthase (post-PKS) tailoring step of the MTM biosynthesis by Streptomyces argillaceus ATCC 12956, which was proposed to be cat...

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Veröffentlicht in:J Am Chem Soc
Hauptverfasser: Remsing, Lily L., González, Ana M., Nur-e-Alam, Mohammad, Fernández-Lozano, M. José, Braña, Alfredo F., Rix, Uwe, Oliveira, Marcos A., Méndez, Carmen, Salas, José A., Rohr, Jürgen
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2003
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4480629/
https://ncbi.nlm.nih.gov/pubmed/12733914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja034162h
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