Ketopremithramycins and Ketomithramycins, Four New Aureolic Acid-Type Compounds Obtained upon Inactivation of Two Genes Involved in the Biosynthesis of the Deoxysugar Moieties of the Antitumor Drug Mithramycin by Streptomyces Argillaceus, Reveal Novel Insights into Post-PKS Tailoring Steps of the Mithramycin Biosynthetic Pathway

Mithramycin is an aureolic acid-type antimicrobial and antitumor agent produced by Streptomyces argillaceus. Modifying post-polyketide synthase (PKS) tailoring enzymes involved in the production of mithramycin is an effective way of gaining further information regarding the late steps of its biosynt...

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Publicado no:J Am Chem Soc
Main Authors: Remsing, Lily L., Garcia-Bernardo, Jose, Gonzalez, Ana, Künzel, Eva, Rix, Uwe, Braña, Alfredo F., Bearden, Daniel W., Méndez, Carmen, Salas, Jose A., Rohr, Jürgen
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4480631/
https://ncbi.nlm.nih.gov/pubmed/11853433
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