A NOVEL MITHRAMYCIN ANALOGUE WITH HIGH ANTITUMOR ACTIVITY AND LESS TOXICITY GENERATED BY COMBINATORIAL BIOSYNTHESIS

Mithramycin is an antitumor compound produced by Streptomyces argillaceus that has been used for the treatment of several types of tumors and hypercalcaemia processes. However, its use in humans has been limited because its side effects. Using combinatorial biosynthesis approaches, we have generated...

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Autori principali: Núñez, Luz E., Nybo, Stephen E., González-Sabín, Javier, Pérez, María, Menéndez, Nuria, Braña, Alfredo F., He, Min, Morís, Francisco, Salas, José A., Rohr, Jürgen, Méndez, Carmen
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3395220/
https://ncbi.nlm.nih.gov/pubmed/22578073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300234t
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