Mithramycin Analogues Generated by Combinatorial Biosynthesis Show Improved Bioactivity

Plasmid pLNBIV was used to overexpress the biosynthetic pathway of nucleoside-diphosphate (NDP)-activatedl-digitoxose in the mithramycin producer Streptomyces argillaceus. This led to a “flooding” of the biosynthetic pathway of the antitumor drug mithramycin (MTM) with NDP-activated deoxysugars, whi...

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Autori principali: Baig, Irfan, Perez, María, Braña, Alfredo F., Gomathinayagam, Rohini, Damodaran, Chendil, Salas, Jose A., Méndez, Carmen, Rohr, Jürgen
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442402/
https://ncbi.nlm.nih.gov/pubmed/18197601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np0705763
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