A NOVEL MITHRAMYCIN ANALOGUE WITH HIGH ANTITUMOR ACTIVITY AND LESS TOXICITY GENERATED BY COMBINATORIAL BIOSYNTHESIS

Mithramycin is an antitumor compound produced by Streptomyces argillaceus that has been used for the treatment of several types of tumors and hypercalcaemia processes. However, its use in humans has been limited because its side effects. Using combinatorial biosynthesis approaches, we have generated...

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主要な著者: Núñez, Luz E., Nybo, Stephen E., González-Sabín, Javier, Pérez, María, Menéndez, Nuria, Braña, Alfredo F., He, Min, Morís, Francisco, Salas, José A., Rohr, Jürgen, Méndez, Carmen
フォーマット: Artigo
言語:Inglês
出版事項: 2012
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Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3395220/
https://ncbi.nlm.nih.gov/pubmed/22578073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300234t
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