Positive Modulation of GABA(B) Receptors Decreased Nicotine Self-administration and Counteracted Nicotine-induced Enhancement of Brain Reward Function in Rats

Acute administration of γ-aminobutyric acid (GABA)-B receptor agonists decreases nicotine, cocaine, ethanol, and heroin self-administration, and also decreases food-maintained responding and suppresses locomotor activity at high doses. GABA(B) receptor positive modulators may represent potentially i...

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Autores principales: Paterson, Neil E., Vlachou, Styliani, Guery, Sebastien, Kaupmann, Klemens, Froestl, Wolfgang, Markou, Athina
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574924/
https://ncbi.nlm.nih.gov/pubmed/18445779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.108.139204
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