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Both GABA(B) receptor activation and blockade exacerbated anhedonic aspects of nicotine withdrawal in rats
Nicotine dependence is maintained by the aversive, depression-like effects of nicotine withdrawal and the rewarding effects of acute nicotine. GABA(B) receptor antagonists exhibit antidepressant-like effects in rodents, whereas GABA(B) receptor agonists attenuate the rewarding effects of nicotine. R...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3060559/ https://ncbi.nlm.nih.gov/pubmed/21262222 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2011.01.009 |
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