Both GABA(B) receptor activation and blockade exacerbated anhedonic aspects of nicotine withdrawal in rats

Nicotine dependence is maintained by the aversive, depression-like effects of nicotine withdrawal and the rewarding effects of acute nicotine. GABA(B) receptor antagonists exhibit antidepressant-like effects in rodents, whereas GABA(B) receptor agonists attenuate the rewarding effects of nicotine. R...

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Main Authors: Vlachou, Styliani, Paterson, Neil E., Guery, Sebastien, Kaupmann, Klemens, Froestl, Wolfgang, Banerjee, Deboshri, Finn, M.G., Markou, Athina
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060559/
https://ncbi.nlm.nih.gov/pubmed/21262222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2011.01.009
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