In vitro and in vivo evidence for shear-induced activation of latent transforming growth factor-β1

Transforming growth factor-β1 (TGF-β1) has potent physiologic and pathologic effects on a variety of cell types at subnanomolar concentrations. Platelets contain 40 times as much TGF-β1 as other cells and secrete it as an inactive (latent) form in complex with latency-associated peptide (LAP), which...

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Detalhes bibliográficos
Main Authors: Ahamed, Jasimuddin, Burg, Nathalie, Yoshinaga, Keiji, Janczak, Christin A., Rifkin, Daniel B., Coller, Barry S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Hemostasis, Thrombosis, and Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2572792/
https://ncbi.nlm.nih.gov/pubmed/18544680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-04-151753
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