Mapping early conformational changes in αIIb and β3 during biogenesis reveals a potential mechanism for αIIbβ3 adopting its bent conformation

Current evidence supports a model in which the low-affinity state of the platelet integrin αIIbβ3 results from αIIbβ3 adopting a bent conformation. To assess αIIbβ3 biogenesis and how αIIbβ3 initially adopts the bent conformation, we mapped the conformational states occupied by αIIb and β3 during bi...

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Bibliographic Details
Main Authors: Beau Mitchell, W., Li, Jihong, Murcia, Marta, Valentin, Nathalie, Newman, Peter J., Coller, Barry S.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2007
Subjects:
Hemostasis, Thrombosis, and Vascular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874580/
https://ncbi.nlm.nih.gov/pubmed/17209052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-11-058420
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