Structural and therapeutic insights from the species specificity and in vivo antithrombotic activity of a novel αIIb-specific αIIbβ3 antagonist

We previously reported on a novel compound (Compound 1; RUC-1) identified by high-throughput screening that inhibits human αIIbβ3. RUC-1 did not inhibit αVβ3, suggesting that it interacts with αIIb, and flexible ligand/rigid protein molecular docking studies supported this speculation. We have now s...

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Detaylı Bibliyografya
Asıl Yazarlar: Blue, Robert, Kowalska, M. Anna, Hirsch, Jessica, Murcia, Marta, Janczak, Christin A., Harrington, Amanda, Jirouskova, Marketa, Li, Jihong, Fuentes, Rudy, Thornton, Michael A., Filizola, Marta, Poncz, Mortimer, Coller, Barry S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2009
Konular:
Thrombosis and Hemostasis
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2710948/
https://ncbi.nlm.nih.gov/pubmed/19414864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-08-169243
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