Structural and therapeutic insights from the species specificity and in vivo antithrombotic activity of a novel αIIb-specific αIIbβ3 antagonist

We previously reported on a novel compound (Compound 1; RUC-1) identified by high-throughput screening that inhibits human αIIbβ3. RUC-1 did not inhibit αVβ3, suggesting that it interacts with αIIb, and flexible ligand/rigid protein molecular docking studies supported this speculation. We have now s...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Blue, Robert, Kowalska, M. Anna, Hirsch, Jessica, Murcia, Marta, Janczak, Christin A., Harrington, Amanda, Jirouskova, Marketa, Li, Jihong, Fuentes, Rudy, Thornton, Michael A., Filizola, Marta, Poncz, Mortimer, Coller, Barry S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2710948/
https://ncbi.nlm.nih.gov/pubmed/19414864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-08-169243
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados