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In Vitro and In Vivo Evidence that Thrombospondin-1 (TSP-1) Contributes to Stirring- and Shear-Dependent Activation of Platelet-Derived TGF-β1

Thrombospondin 1 (TSP-1), which is contained in platelet α-granules and released with activation, has been shown to activate latent TGF-β1 in vitro, but its in vivo role is unclear as TSP-1-null (Thbs1(−/−)) mice have a much less severe phenotype than TGF-β1-null (Tgfb1(−/−)) mice. We recently demon...

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Detalles Bibliográficos
Main Authors: Ahamed, Jasimuddin, Janczak, Christin A., Wittkowski, Knut M., Coller, Barry S.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719874/
https://ncbi.nlm.nih.gov/pubmed/19672301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006608
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