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In Vitro and In Vivo Evidence that Thrombospondin-1 (TSP-1) Contributes to Stirring- and Shear-Dependent Activation of Platelet-Derived TGF-β1
Thrombospondin 1 (TSP-1), which is contained in platelet α-granules and released with activation, has been shown to activate latent TGF-β1 in vitro, but its in vivo role is unclear as TSP-1-null (Thbs1(−/−)) mice have a much less severe phenotype than TGF-β1-null (Tgfb1(−/−)) mice. We recently demon...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2719874/ https://ncbi.nlm.nih.gov/pubmed/19672301 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006608 |
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